Protein wntless (wls) Recombinant Protein | DyakGE20230 recombinant protein
Recombinant Drosophila yakuba Protein wntless (wls)
NCBI and Uniprot Product Information
Uniprot Description
Function: A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip
By similarity. UniProtKB Q95ST2
Subunit structure: Interacts with wg; in the Golgi. Interacts with Vps35, a component of the retromer complex; wls stability is regulated by Vps35
By similarity. UniProtKB Q95ST2
Subcellular location: Cell junction › synapse › presynaptic cell membrane; Multi-pass membrane protein
By similarity. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein
By similarity. Cell membrane; Multi-pass membrane protein
By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein
By similarity. Endosome membrane; Multi-pass membrane protein
By similarity. Golgi apparatus membrane; Multi-pass membrane protein
By similarity. Note: In non-neuronal cells, wls binds to wg in the Golgi and accompanies it to the plasma membrane where the two proteins dissociate. Wg is secreted and wls is then internalized and returns to the Golgi apparatus in a retromer-dependent manner. Wls and wg colocalize in the Golgi apparatus in wg-producing cells, and reduced expression is seen in non-producing cells. Endoplasmic recticulum expression is unchanged in wg-producing versus non-producing cells. In neuronal cells, wls is localized both pre- and postsynaptically and is transferred trans-synaptically from the pre- to the postsynaptic compartment
By similarity. UniProtKB Q95ST2
Sequence similarities: Belongs to the wntless family.
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Product Notes
The DyakGE20230 wls (Catalog #AAA1144939) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 36-562. The amino acid sequence is listed below: APLPAGHVTV LGSLCREDHG RQNDTGFLLY SRGAGACIPV TREEVEQDST KMANELVHVF QMPLPRDLRD LDYSRWQQNL IGVLQVEFGY DSSSELREPP RELQLTIDMR LAYRNKGDPD NGWKLYAHGV EHRYLDCVTS HVGPTETLYS CDMIPLFELG ALHHSFYLLN LRFPLDTPSQ MNLQFGHMHD LTLTAIHQNG GFTQIWLLLK TMLFPFVVGI MIWFWRRVHL LQRSPALLEY MLIYLGAALT FLNLPLEYLS LVYEMPYMLL LSDIRQGIFY AMLLTFWLVF AGEHMLIQDA PNKSTIRSRY WKHLSAVVVG CISLFVFDIC ERGVQLRNPF YSIWTTPLGA KVAMTFIVLA GVSAAIYFLF LCYMIWKVFR NIGDKRTSLP SMSQARRLHY EGLIYRFKFL MLATLVCAAL TVAGFVMGQM AEGQWDWNDN VAIQPTSAFL TGVYGMWNIY IFALLILYAP SHKQWPTMHH SDETTQSNEN IVASAASEEI EFNHLPSDSN PSEISSLTSF TRKVAFD. It is sometimes possible for the material contained within the vial of "Protein wntless (wls), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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