WPP domain-interacting tail-anchored protein 2 (WIT2) Recombinant Protein | WIT2 recombinant protein

Recombinant Arabidopsis thaliana WPP domain-interacting tail-anchored protein 2 (WIT2) , partial

• Gene Names: WIT2; T6L1.9; T6L1_9; WPP domain-interacting protein 2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: WPP domain-interacting tail-anchored protein 2 (WIT2); Recombinant Arabidopsis thaliana WPP domain-interacting tail-anchored protein 2 (WIT2); partial; WIT2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 582

• Species: Arabidopsis thaliana (Mouse-ear cress)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 145327191
• NCBI GeneID: 843224
• NCBI Accession #: NP_001077797.1
• NCBI GenBank Nucleotide #: NM_001084328.2
• UniProt Accession #: A8MQR0; Q9CAB0
• Molecular Weight: 66,440 Da
• NCBI Official Full Name: WPP domain-interacting protein 2
• NCBI Official Symbol: WIT2
• NCBI Official Synonym Symbols: T6L1.9; T6L1_9; WPP domain-interacting protein 2
• NCBI Protein Information: WPP domain-interacting protein 2
• UniProt Protein Name: WPP domain-interacting tail-anchored protein 2
• Protein Family: WPP domain-interacting tail-anchored protein
• UniProt Gene Name: WIT2

NCBI Description

Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.

Uniprot Description

Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips (PubMed:18591351). Plays a role in nuclear shape determination (PubMed:25759303). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303).