WPP domain-interacting tail-anchored protein 2 (WIT2) Recombinant Protein | WIT2 recombinant protein
Recombinant Arabidopsis thaliana WPP domain-interacting tail-anchored protein 2 (WIT2)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
Uniprot Description
Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips.
Research Articles on WIT2
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Product Notes
The WIT2 wit2 (Catalog #AAA7033600) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-627aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the WIT2 wit2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MEEIIREDYF EALSSRNEEE QEMLRMLTKL EIDSAYTSEK LMNLHVLLMH LLAWDNDLEG MGTLDSSPAS FEKALTFDLL CGILESEVKE VDEVLDVLEA QIVDTSYKIS SCKHGNYIVI EGKLGESAES LKQSRGQVSE ITLQLAQLRR TLHYIRNGTS ENEESVELRQ KYALKPSDLR HKNALRMLEK SLSRELELEK KLMEFQQNEE QLKLKLHYTE EVSSRMEEAS EFIWGRFLEA DNSSEVLTGI SKELVGRLQI LQFSLNGSAQ RESELKSKLE DCTVQLEAKD LLVQKLEGTI SENSEIVSEV LTLREYVKSA EQKLKNTDLE LKSVNASKQE ILVHLAEMEN ANESVKENLF EAESRAESGE AKIKELDAAN LELTEELNFL KDADDKKTKK VNSLEKQVRE LEVQVQNSKV SSEANQEQQN MLYSAIWDME TLIEDLKSKA SKAESRTETV EEQCIVLSTT NSELNKDVSF LRQKAKSLEA MLDLANNEKE RYAQEITTRN KVLMDMMLQL SSERERIQEQ LYSLAKENKI LRVNQCSNTY QRNGSYAGDK ELSFHADGHE IEALAESLQE DERTREEPEK QSVSEKSSEI RRAIKLKHIL VVALVFVLFC SFFGVTY. It is sometimes possible for the material contained within the vial of "WPP domain-interacting tail-anchored protein 2 (WIT2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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