WAP Four-Disulfide Core Domain 2 Recombinant Protein | WFDC2 recombinant protein

Recombinant Human WAP Four-Disulfide Core Domain 2

Cat. Num. AAA146331

• Gene Names: WFDC2; HE4; WAP5; EDDM4; dJ461P17.6
• Purity: Purity as determined by densitometric image analysis is greater than 95%.
• Synonyms: WAP Four-Disulfide Core Domain 2; Recombinant Human WAP Four-Disulfide Core Domain 2; WFDC2 Human; WAP Four-Disulfide Core Domain 2 Human Recombinant; WAP four-disulfide core domain protein 2; Epididymal secretory protein E4; Major epididymis-specific protein E4; Putative protease inhibitor WAP5; WFDC2; HE4; WAP5; EDDM4; dJ461P17.6; WFDC2 recombinant protein

• Host: E Coli
• Purity/Purification: Purity as determined by densitometric image analysis is greater than 95%.
• Form/Format: WFDC2 filtered (0.4 um) and lyophilized from 0.5mg/ml in PBS buffer, pH 7.5.; Filtered White lyophilized (freeze-dried) powder.
• Sequence: MKHHHHHHASEKTGVCPELQ ADQNCTQECV SDSECADNLK CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD SQCPGQMKCC RNGCGKVSCV TPNF.
• Sequence Length: 124

• Solubility: It is recommended to add 200 ul deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. WFDC2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
• Preparation and Storage: Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Related Product Information for WFDC2 recombinant protein

Description: WFDC2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (31-124) containing 104 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 11.3kDa (calculated).

Introduction: WAP four-disulfide core domain protein 2 (WFDC2) is a protease inhibitor, which belongs to the WFDC domain family. WFDC2 is effective with a broad range of proteases, e.g. aspartic, serine or thiol proteases. WFDC2 is expressed in several normal tissues, including the male reproductive system, regions of the respiratory tract and nasopharynx. WFDC2 may be involved in sperm maturation. WFDC2 is also highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.

Product Categories/Family for WFDC2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 56699495
• NCBI GeneID: 10406
• NCBI Accession #: NP_006094.3
• NCBI GenBank Nucleotide #: NM_006103.3
• UniProt Accession #: Q14508; Q6IB27; Q8WXV9; Q8WXW0; Q8WXW1; Q8WXW2; Q96KJ1; A2A2A5; A2A2A6; A6PVD5
• Molecular Weight: 11,043 Da
• NCBI Official Full Name: WAP four-disulfide core domain protein 2
• NCBI Official Synonym Full Names: WAP four-disulfide core domain 2
• NCBI Official Symbol: WFDC2
• NCBI Official Synonym Symbols: HE4; WAP5; EDDM4; dJ461P17.6
• NCBI Protein Information: WAP four-disulfide core domain protein 2; WAP domain containing protein HE4-V4; epididymal protein 4; epididymal secretory protein E4; epididymis-specific, whey-acidic protein type, four-disulfide core; major epididymis-specific protein E4; putative protease inhibitor WAP5
• UniProt Protein Name: WAP four-disulfide core domain protein 2
• Protein Family: WAP four-disulfide core domain protein
• UniProt Gene Name: WFDC2
• UniProt Synonym Gene Names: HE4; WAP5
• UniProt Entry Name: WFDC2_HUMAN

NCBI Description

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Uniprot Description

WFDC2: a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity; aspartic-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; cysteine protease inhibitor activity

Biological Process: spermatogenesis; proteolysis