Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) Western Blot Control | GM-CSF western blot control

Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) (Western Blot Control)

Cat. Num. AAA343038

• Purity: >= 95% (SDS PAGE)
• Synonyms: Granulocyte Macrophage Colony Stimulating Factor (GM-CSF); Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) (Western Blot Control); Granulocyte Macrophage Colony Stimulating Factor; CSF-2; MGI-1GM; GM-CSF; Pluripoietin-alpha; Molgramostin; Sargramostim; MGC131935; MGC138898; GM-CSF western blot control

• Purity/Purification: >= 95% (SDS PAGE)
• Form/Format: Liquid
• Sequence Length: 144

• Buffer: Buffered 50% glycerol

Related Product Information for GM-CSF western blot control

GM-CSF is a potent species-specific growth factor produced by a variety of cell types including T cells, B cells, macrophages, mast cells and endothelial cells. GM-CSF is produced in response to cytokine or immune stimulation and has been shown to stimulate the proliferation, maturation and function of hematopoietic cells. Recombinant GM-CSF comprises a 127 amino acid fragment (18-144) corresponding to the mature GM-CSF protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Product Categories/Family for GM-CSF western blot control

Recombinant Proteins; GM-CSF

References

Burgess, A.W. et al. (1987) Blood 69 (1): 43-51 Metcalf, D et al. (1986) Blood 67 (1): 37-45.

NCBI and Uniprot Product Information

• NCBI GI #: 27437030
• NCBI GeneID: 1437
• NCBI Accession #: NP_000749.2
• NCBI GenBank Nucleotide #: NM_000758.3
• UniProt Accession #: P04141; Q14CE8; Q2VPI8; Q8NFI6
• Molecular Weight: 16,295 Da
• NCBI Official Full Name: granulocyte-macrophage colony-stimulating factor
• UniProt Protein Name: Granulocyte-macrophage colony-stimulating factor
• UniProt Gene Name: CSF2
• UniProt Synonym Gene Names: GMCSF; GM-CSF; CSF
• UniProt Entry Name: CSF2_HUMAN

Uniprot Description

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular region

Molecular Function: protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: MAPKKK cascade; myeloid dendritic cell differentiation; negative regulation of cytolysis; positive regulation of DNA replication; positive regulation of interleukin-23 production; positive regulation of tyrosine phosphorylation of Stat5 protein