Fractalkine Western Blot Control | CX3CL1 western blot control

Fractalkine (Western Blot Control)

Cat. Num. AAA343189

• Gene Names: CX3CL1; NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin
• Purity: >= 95% (SDS PAGE)
• Synonyms: Fractalkine; Fractalkine (Western Blot Control); Chemokine; CX3C Motif; Ligand 1; CX3CL1; Small Inducible Cytokine Subfamily D; Member 1; SCYD1; Neurotactin; NTT; NTN; CX3CL1 western blot control

• Purity/Purification: >= 95% (SDS PAGE)
• Form/Format: Liquid
• Sequence Length: 397

• Buffer: Buffered 50% glycerol

Related Product Information for CX3CL1 western blot control

Fractalkine is a large cytokine protein containing multiple domains and is the only known member of the CX3C chemokine family. Fractalkine is produced as a long protein (with 373-amino acid in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. Fractalkine elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Recombinant Fractalkine comprises a 76 amino acid fragment (25-100) corresponding to the chemokine domain of the fractalkine protein and is expressed in E Coli with an aminoterminal hexahistidine tag. This product is not intended for therapeutic use

Product Categories/Family for CX3CL1 western blot control

Recombinant Proteins; Fractalkine

References

Pan, Y. et al. (1997) Nature 387: 611-617. Bazan, J.F. et al. (1997) Nature 385: 640-644.

NCBI and Uniprot Product Information

• NCBI GI #: 4506857
• NCBI GeneID: 6376
• NCBI Accession #: NP_002987.1
• NCBI GenBank Nucleotide #: NM_002996.4
• UniProt Accession #: P78423; O00672
• Molecular Weight: 42,203 Da
• NCBI Official Full Name: fractalkine isoform 1
• NCBI Official Synonym Full Names: C-X3-C motif chemokine ligand 1
• NCBI Official Symbol: CX3CL1
• NCBI Official Synonym Symbols: NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin
• NCBI Protein Information: fractalkine
• UniProt Protein Name: Fractalkine
• Protein Family: Fractalkine
• UniProt Gene Name: CX3CL1
• UniProt Synonym Gene Names: FKN; NTT; SCYD1
• UniProt Entry Name: X3CL1_HUMAN

Uniprot Description

CX3CL1: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: cell surface; extracellular region; extracellular space; integral to membrane; plasma membrane

Molecular Function: CCR chemokine receptor binding; chemokine activity; CX3C chemokine receptor binding; integrin binding; protein binding; receptor binding

Biological Process: chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; G-protein coupled receptor protein signaling pathway; immune response; integrin activation; leukocyte adhesive activation; leukocyte chemotaxis; leukocyte migration during inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of calcium-independent cell-cell adhesion; positive regulation of GTPase activity; positive regulation of inflammatory response