WD repeat-containing and planar cell polarity effector protein fritz homolog Recombinant Protein | Wdpcp recombinant protein

Recombinant Mouse WD repeat-containing and planar cell polarity effector protein fritz homolog

Cat. Num. AAA1265322

• Gene Names: Wdpcp; AV249152
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: WD repeat-containing and planar cell polarity effector protein fritz homolog; Recombinant Mouse WD repeat-containing and planar cell polarity effector protein fritz homolog; Homolog-13WD repeat-containing and planar cell polarity effector protein; Wdpcp recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-722aa; Full Length
• Sequence: MSFCLTELHLWSLKSTLHIADRDIGVYQYYDKKDPSVSATEHGNLEEKQRLAESRDYPWTLKNRRPEKLRDSLKELEELMQSSPCVLSKWKSKYICQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMDSLDGNKRLEKLSALDLKISYYDIPGPANRTIDRHLAVNSTQDLVVCWWPLVSDDVWPWTPVSSEKDRANMLLLGFTQGGLEVLSFVRTEWSPLDVHFGTKQPYQVFTVECSVSVDKEPMADSCIYESVRNKLHCVSVTRIPLRSKAISCCRNSTEDKLIVGCEDSSVILYEAHRGVTLLAQAELRPSLISCHPSGAILLVGSNQGELQIFDIALSPINIQLLAEDYSPKETLQFKKFFDVSSSLVQMQWMAPPVVFQKPKRGEICDLLFLRFNKGPLGVLLFKLGILTRGQLGLVDLILQYIHYSEVYEAISILRSMDWDTLGQQCLIGMGTIVNHLLRQRLTPEREAQLEASLGTFYAPTRPLLDTTILEYREPVSKYARRLFHHLLRYKRFEKAFLLAVDIGARDLFMDIHYLALDMGELALAEVARRRAHDIDVESVSSGVELLGPLDRRDMLNEGFASSALMPEGENKFPGLLPSIGSTHMQTLQQKIPNGPSSRWAIERRTEEEEEEEEEEEEELCTDSSGATTWNAEGELKEDQRKQDIGDVGSLRMVHFGLV
• Sequence Length: 643

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Wdpcp recombinant protein

Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movents.

References

Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14.Fuchs S., Resch K., Thiel C., Ulbrich M., Platzer M., Jockusch H., Schmitt-John T.BMC Genet. 3:14-14(2002)

NCBI and Uniprot Product Information

• NCBI GeneID: 216560
• UniProt Accession #: Q8C456; Q8BRR5; Q91ZJ2
• Molecular Weight: 108.7 kDa
• NCBI Official Synonym Full Names: WD repeat containing planar cell polarity effector
• NCBI Official Symbol: Wdpcp
• NCBI Official Synonym Symbols: AV249152
• NCBI Protein Information: WD repeat-containing and planar cell polarity effector protein fritz homolog
• UniProt Protein Name: WD repeat-containing and planar cell polarity effector protein fritz homolog
• Protein Family: WD repeat-containing and planar cell polarity effector protein
• UniProt Gene Name: Wdpcp
• UniProt Synonym Gene Names: mFrtz
• UniProt Entry Name: FRITZ_MOUSE

Uniprot Description

LOC51057: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Defects in WDPCP are the cause of Bardet-Biedl syndrome type 15 (BBS15). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Mutations in WDPCP may act as modifiers of the phenotypic expression of Bardet-Biedl syndrome and Meckel syndrome by interacting in trans with primary BBS and MKS loci. Belongs to the WD repeat fritz family. 3 isoforms of the human protein are produced by alternative splicing.

Cellular Component: cell projection; cilium; cytoplasm; cytoskeleton; membrane; plasma membrane

Molecular Function: protein binding

Biological Process: auditory receptor cell morphogenesis; camera-type eye development; cell projection organization and biogenesis; cilium biogenesis; embryonic digit morphogenesis; embryonic organ development; establishment of protein localization; kidney development; nervous system development; palate development; regulation of focal adhesion formation; smoothened signaling pathway