WD repeat and FYVE domain-containing protein 3 (Wdfy3) Recombinant Protein | Wdfy3 recombinant protein

Recombinant Mouse WD repeat and FYVE domain-containing protein 3 (Wdfy3) , partial

• Gene Names: Wdfy3; ALFY; BWF1; Bchs; Ggtb3; ZFYVE25; AW319683; D5Ertd66e; mKIAA0993; B930017C24; 2610509D04Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: WD repeat and FYVE domain-containing protein 3 (Wdfy3); Recombinant Mouse WD repeat and FYVE domain-containing protein 3 (Wdfy3); partial; Wdfy3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 913

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Wdfy3 recombinant protein

This gene encodes a protein which contains WD repeats and an FYVE domain. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

NCBI and Uniprot Product Information

• NCBI GI #: 39930599
• NCBI GeneID: 72145
• NCBI Accession #: NP_766470.2
• NCBI GenBank Nucleotide #: NM_172882.3
• UniProt Accession #: Q6VNB8; Q8C8H7
• Molecular Weight: 102,219 Da
• NCBI Official Full Name: WD repeat and FYVE domain-containing protein 3
• NCBI Official Synonym Full Names: WD repeat and FYVE domain containing 3
• NCBI Official Symbol: Wdfy3
• NCBI Official Synonym Symbols: ALFY; BWF1; Bchs; Ggtb3; ZFYVE25; AW319683; D5Ertd66e; mKIAA0993; B930017C24; 2610509D04Rik
• NCBI Protein Information: WD repeat and FYVE domain-containing protein 3
• UniProt Protein Name: WD repeat and FYVE domain-containing protein 3
• Protein Family: WD repeat and FYVE domain-containing protein
• UniProt Gene Name: Wdfy3
• UniProt Synonym Gene Names: BWF1

Uniprot Description

Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (). Important for normal brain development (PubMed:25198012, PubMed:27648578). Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (PubMed:27648578). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (PubMed:27330028). After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) ().