Structure
VU 29, Inhibitor | VU29, inhibitor
VU 29
Purity
98.00%
Synonyms
VU 29; VU29; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: <38.44mg/ml
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H16N4O3
SMILES
[O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
CAS Number
890764-36-0
Target & IC50
rat mGluR5: ic50 224nM (Ki)
rat mGluR1: ic50 557nM (EC50)
rat mGluR2: ic50 1.5uM (EC50)
hmGluR4: ic50 154nM (EC50)
rat mGluR1: ic50 557nM (EC50)
rat mGluR2: ic50 1.5uM (EC50)
hmGluR4: ic50 154nM (EC50)
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for VU29, inhibitor
VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9nM and Ki=244nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557nM/1.5uM; hmGluR4=154nM).
Product Categories/Family for VU29, inhibitor
References
Chen Y, Nong Y, Goudet C, et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.[J]. Molecular Pharmacology, 2007, 71(5):1389-1398.
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Product Notes
The VU29 (Catalog #AAA5757970) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "VU 29, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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