Polycomb group protein VERNALIZATION 2 (VRN2) Recombinant Protein | VRN2 recombinant protein

Recombinant Arabidopsis thaliana Polycomb group protein VERNALIZATION 2 (VRN2)

Cat. Num. AAA1377426

• Gene Names: VRN2; REDUCED VERNALIZATION RESPONSE 2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Polycomb group protein VERNALIZATION 2 (VRN2); Recombinant Arabidopsis thaliana Polycomb group protein VERNALIZATION 2 (VRN2); VRN2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-440, Full length protein
• Sequence: MCRQNCRAKSSPEEVISTDENLLIYCKPVRLYNIFHLRSLGNPSFLPRCLNYKIGAKRKRKSRSTGMVVFNYKDCNNTLQRTEVREDCSCPFCSMLCGSFKGLQFHLNSSHDLFEFEFKLLEEYQTVNVSVKLNSFIFEEEGSDDDKFEPFSLCSKPRKRRQRGGRNNTRRLKVCFLPLDSPSLANGTENGIALLNDGNRGLGYPEATELAGQFEMTSNIPPAIAHSSLDAGAKVILTTEAVVPATKTRKLSAERSEARSHLLLQKRQFYHSHRVQPMALEQVMSDRDSEDEVDDDVADFEDRQMLDDFVDVNKDEKQFMHLWNSFVRKQRVIADGHISWACEVFSRFYEKELHCYSSLFWCWRLFLIKLWNHGLVDSATINNCNTILENCRNTSVTNNNNNSVDHPSDSNTNNNNIVDHPNDIKNKNNVDNKDNNSRDK
• Sequence Length: 440

• Species: Arabidopsis thaliana (Mouse-ear cress)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 18414761
• NCBI GeneID: 827392
• NCBI Accession #: NP_567517.1
• NCBI GenBank Nucleotide #: NM_117787.4
• UniProt Accession #: Q8W5B1; O23524; O23525; Q8W5B2; Q94CF5
• Molecular Weight: 12,421 Da
• NCBI Official Full Name: VEFS-Box of polycomb protein
• NCBI Official Symbol: VRN2
• NCBI Official Synonym Symbols: REDUCED VERNALIZATION RESPONSE 2
• NCBI Protein Information: VEFS-Box of polycomb protein
• UniProt Protein Name: Polycomb group protein VERNALIZATION 2
• Protein Family: Polycomb group protein
• UniProt Gene Name: VRN2

NCBI Description

The VERNALIZATION2 (VRN2) gene mediates vernalization and encodes a nuclear-localized zinc finger protein with similarity to Polycomb group (PcG) proteins of plants and animals. In wild-type Arabidopsis, vernalization results in the stable reduction of the levels of the floral repressor FLC. In vrn2 mutants, FLC expression is downregulated normally in response to vernalization, but instead of remaining low, FLC mRNA levels increase when plants are returned to normal temperatures. VRN2 maintains FLC repression after a cold treatment, serving as a mechanism for the cellular memory of vernalization. Required for complete repression of FLC. Required for the methylation of histone H3

Uniprot Description

Polycomb group (PcG) protein. Plays a central role in vernalization by maintaining repressed the homeotic gene FLC, a floral repressor, after a cold treatment. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Associates constitutively along the whole FLC locus.