Vacuolar protein sorting-associated protein 41 homolog (VPS41) Recombinant Protein | VPS41 recombinant protein

Recombinant Human Vacuolar protein sorting-associated protein 41 homolog (VPS41) , partial

• Gene Names: VPS41; HVPS41; HVSP41; hVps41p
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Vacuolar protein sorting-associated protein 41 homolog (VPS41); Recombinant Human Vacuolar protein sorting-associated protein 41 homolog (VPS41); partial; VPS41 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 854

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for VPS41 recombinant protein

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known.

NCBI and Uniprot Product Information

• NCBI GI #: 114199475
• NCBI GeneID: 27072
• NCBI Accession #: NP_055211.2
• NCBI GenBank Nucleotide #: NM_014396.3
• UniProt Accession #: P49754; Q86TP8; Q99851; Q99852; E9PF36
• Molecular Weight: 95,924 Da
• NCBI Official Full Name: vacuolar protein sorting-associated protein 41 homolog isoform 1
• NCBI Official Synonym Full Names: VPS41, HOPS complex subunit
• NCBI Official Symbol: VPS41
• NCBI Official Synonym Symbols: HVPS41; HVSP41; hVps41p
• NCBI Protein Information: vacuolar protein sorting-associated protein 41 homolog
• UniProt Protein Name: Vacuolar protein sorting-associated protein 41 homolog
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VPS41

NCBI Description

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]

Uniprot Description

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660).