Canine Very Low Density Lipoprotein Receptor ELISA Kit | VLDLR elisa kit

Canine Very Low Density Lipoprotein Receptor ELISA Kit

Cat. Num. AAA38857

• Gene Names: VLDLR; CARMQ1; CHRMQ1; VLDLRCH
• Reactivity: Canine
• Synonyms: Very Low Density Lipoprotein Receptor; Canine Very Low Density Lipoprotein Receptor ELISA Kit; VLDLR elisa kit

• Reactivity: Canine

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 65301167
• NCBI GeneID: 7436
• NCBI Accession #: NP_003374.3
• NCBI GenBank Nucleotide #: NM_003383.3
• UniProt Accession #: P98155; Q5VVF6; B2RMZ7; D3DRH6
• Molecular Weight: 96,098 Da
• NCBI Official Full Name: very low-density lipoprotein receptor isoform a
• NCBI Official Synonym Full Names: very low density lipoprotein receptor
• NCBI Official Symbol: VLDLR
• NCBI Official Synonym Symbols: CARMQ1; CHRMQ1; VLDLRCH
• NCBI Protein Information: very low-density lipoprotein receptor; VLDL-R; VLDL receptor
• UniProt Protein Name: Very low-density lipoprotein receptor
• Protein Family: Very low-density lipoprotein receptor
• UniProt Gene Name: VLDLR
• UniProt Synonym Gene Names: VLDL receptor; VLDL-R
• UniProt Entry Name: VLDLR_HUMAN

NCBI Description

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: membrane; plasma membrane; integral to membrane; coated pit; receptor complex

Molecular Function: low-density lipoprotein receptor activity; very-low-density lipoprotein receptor activity; very-low-density lipoprotein binding; protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; calcium-dependent protein binding

Biological Process: receptor-mediated endocytosis; nervous system development; cholesterol metabolic process; positive regulation of protein kinase activity; ventral spinal cord development; negative regulation of transcription from RNA polymerase II promoter; signal transduction; lipid transport; memory

Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1