Rat Versican core protein ELISA Kit | Vcan elisa kit

Rat Versican core protein ELISA Kit

Cat. Num. AAA2882625

• Gene Names: Vcan; Cspg2
• Reactivity: Rat
• Synonyms: Versican core protein; Rat Versican core protein ELISA Kit; Chondroitin sulfate proteoglycan core protein 2; Chondroitin sulfate proteoglycan 2; Glial hyaluronate-binding protein; GHAP; Large fibroblast proteoglycan; PG-M; Vcan; Vcan elisa kit

• Reactivity: Rat
• Sequence Length: 3357

• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 281604090
• NCBI GeneID: 114122
• NCBI Accession #: NP_001164029.1
• NCBI GenBank Nucleotide #: NM_001170558.1
• UniProt Accession #: Q9ERB4; O08592; O88564; Q9R1K4
• Molecular Weight: 296,869 Da
• NCBI Official Full Name: versican core protein isoform 1
• NCBI Official Synonym Full Names: versican
• NCBI Official Symbol: Vcan
• NCBI Official Synonym Symbols: Cspg2
• NCBI Protein Information: versican core protein
• UniProt Protein Name: Versican core protein
• Protein Family: Versican core protein
• UniProt Gene Name: Vcan
• UniProt Synonym Gene Names: Cspg2; Chondroitin sulfate proteoglycan 2; GHAP
• UniProt Entry Name: CSPG2_RAT

NCBI Description

extracellular matrix protein secreted by many cell types; part of the large chondroitin sulfate proteoglycan (CSPG) family [RGD, Feb 2006]

Uniprot Description

CSPG2: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1). WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN. Belongs to the aggrecan/versican proteoglycan family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Secreted; Secreted, signal peptide

Cellular Component: cell surface; extracellular matrix; extracellular region; extracellular space; intracellular membrane-bound organelle; membrane; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; carbohydrate binding; hyaluronic acid binding; low-density lipoprotein binding; protein phosphatase binding

Biological Process: axon regeneration; cell adhesion; central nervous system development; glial cell migration; heart development; osteoblast differentiation; response to wounding; skeletal development