Human ubiquitously-expressed transcript ELISA Kit | UXT elisa kit

Human Protein UXT, UXT ELISA Kit

Cat. Num. AAA9327784

• Gene Names: UXT; STAP1; ART-27
• Reactivity: Human
• Synonyms: ubiquitously-expressed transcript; Human Protein UXT; UXT ELISA Kit; Human Protein UXT (UXT) ELISA kit; RP1-212G6.2; ART-27; STAP1; SKP2-associated alpha PFD 1; UXT elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 4759298
• NCBI GeneID: 8409
• NCBI Accession #: NP_004173.1
• NCBI GenBank Nucleotide #: NM_004182.3
• UniProt Accession #: Q9UBK9; Q5JZG3; Q9Y6E5; B2R561
• Molecular Weight: 18,246 Da
• NCBI Official Full Name: protein UXT isoform 2
• NCBI Official Synonym Full Names: ubiquitously-expressed, prefoldin-like chaperone
• NCBI Official Symbol: UXT
• NCBI Official Synonym Symbols: STAP1; ART-27
• NCBI Protein Information: protein UXT; SKP2-associated alpha PFD 1; ubiquitously expressed transcript protein; androgen receptor trapped clone 27 protein
• UniProt Protein Name: Protein UXT
• Protein Family: Protein
• UniProt Gene Name: UXT
• UniProt Synonym Gene Names: HSPC024; ART-27
• UniProt Entry Name: UXT_HUMAN

NCBI Description

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

UXT: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region. Belongs to the UXT family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xp11.23-p11.22

Cellular Component: centrosome; cytoskeleton; cytoplasm; nucleus; gamma-tubulin complex

Molecular Function: actin filament binding; protein binding; microtubule binding; beta-tubulin binding; chromatin binding

Biological Process: transcription, DNA-dependent; centrosome organization and biogenesis; microtubule cytoskeleton organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; mitochondrion transport along microtubule