UvrABC system protein B (uvrB) Recombinant Protein | uvrB recombinant protein

Recombinant Microcystis aeruginosa UvrABC system protein B (uvrB)

Cat. Num. AAA1046232

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: UvrABC system protein B (uvrB); Recombinant Microcystis aeruginosa UvrABC system protein B (uvrB); Recombinant UvrABC system protein B (uvrB); UvrABC system protein B; Protein UvrB; Excinuclease ABC subunit B; uvrB recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-667
• Sequence: MTAFQLQAPFQPTGDQPAAIDQLVDSLQNQHRFQTLLGATGTGKTFTIAAVIEKIGRPTLVLAHNKTLAAQLCNELRQFFPNNAVEYFISYYDYYQPEAYIPVSDTYIEKSSSINDEIDMLRHSATRSLFERRDVIVVASISCIYGLGMPAEYLKAAISLTVGQEFDQRQLLRALVSVQYNRNDLELTRGRFRLKGDILEIVPAYEDRVIKIDFFGDEIESIRYLDPLTGEVLQKLERISIYPARHFVTPEERLEVACRDIKTELDNRLLELEKAGKLLEAQRLDQRTRYDLEMLQEVGYCNGVENYSRHLAGRLAGEPPECLVDYFPEDWLLVVDESHVSVPQIRGMYNGDQSRKKVLIDHGFRLPSAADNRPLKSEEFWQKVNQCIFVSATPGDWELEQSENRIVEQIIRPTGVLDPEIFVRPTEGQVDDLLGEIKERVQLNERVLITTLTKRMAEDLTEYLQERGIKVRYLHSEIQSIQRIEIIQDLREGVFDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRATRSLIQTIGRAARHIRGQAILYGDNLTDSMINAIEETKRRRAIQQEYNQKHGIIPQPIVKRSSNSILAFLDISRRLNSQQLEQVCENIEELSLEQIPELIQQLEAQMKEAAKNLEFESAAKYRDRIKQLRDKLLNHVR
• Sequence Length: 667

• Species: Microcystis aeruginosa (strain NIES-843)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 166366874
• NCBI GeneID: 5864963
• NCBI Accession #: YP_001659147.1
• NCBI GenBank Nucleotide #: NC_010296.1
• UniProt Accession #: B0JR86
• Molecular Weight: 76,625 Da
• NCBI Official Full Name: excinuclease ABC subunit B
• NCBI Official Symbol: uvrB
• NCBI Protein Information: excinuclease ABC subunit B
• UniProt Protein Name: UvrABC system protein B
• Protein Family: UvrABC system protein
• UniProt Gene Name: uvrB
• UniProt Synonym Gene Names: Protein UvrB
• UniProt Entry Name: UVRB_MICAN

Uniprot Description

Function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage

By similarity. HAMAP-Rule MF_00204

Subunit structure: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex

By similarity.

Subcellular location: Cytoplasm

By similarity HAMAP-Rule MF_00204.

Domain: The beta-hairpin motif is involved in DNA binding

By similarity. HAMAP-Rule MF_00204

Sequence similarities: Belongs to the UvrB family.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.Contains 1 UVR domain.