Human ubiquitin specific peptidase 9, X-linked ELISA Kit | USP9X elisa kit
Human Probable ubiquitin carboxyl-terminal hydrolase FAF-X, USP9X ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
USP9X: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin. Widely expressed in embryonic and adult tissues. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.19.12; Ubiquitin-specific protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: Xp11.4
Cellular Component: growth cone; membrane; apical part of cell; cytoplasm; cytosol
Molecular Function: protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; cysteine-type peptidase activity
Biological Process: transcription initiation from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; mitosis; protein deubiquitination; transcription, DNA-dependent; axon extension; in utero embryonic development; hippocampus development; neuron migration; female gamete generation; negative regulation of transcription from RNA polymerase II promoter; cerebellar cortex structural organization; chromosome segregation; post-embryonic development; BMP signaling pathway; cell division; transforming growth factor beta receptor signaling pathway; gene expression
Disease: Mental Retardation, X-linked 99
Research Articles on USP9X
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Product Notes
The Human USP9X usp9x (Catalog #AAA9326099) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326099 ELISA Kit recognizes Human USP9X. It is sometimes possible for the material contained within the vial of "ubiquitin specific peptidase 9, X-linked, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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