Human ubiquitin specific peptidase 6 (Tre-2 oncogene) ELISA Kit | USP6 elisa kit
Human Ubiquitin carboxyl-terminal hydrolase 6, USP6 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
USP6: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.12; Oncoprotein
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: recycling endosome; lysosome; cytoplasm; plasma membrane
Molecular Function: calmodulin binding; protein binding; nucleic acid binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein modification process
Research Articles on USP6
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Product Notes
The Human USP6 usp6 (Catalog #AAA9335433) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335433 ELISA Kit recognizes Human USP6. It is sometimes possible for the material contained within the vial of "ubiquitin specific peptidase 6 (Tre-2 oncogene), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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