Human ubiquitin specific peptidase 33 ELISA Kit | USP33 elisa kit
Human Ubiquitin carboxyl-terminal hydrolase 33, USP33 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Uniprot Description
USP33: Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta- arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase C19 family. USP20/USP33 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.19.12; Ubiquitin-specific protease; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1p31.1
Cellular Component: Golgi apparatus; centrosome; intermediate filament cytoskeleton; perinuclear region of cytoplasm; cytoplasm; VCB complex; autophagic vacuole
Molecular Function: protein binding; ubiquitin binding; G-protein-coupled receptor binding; zinc ion binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; Ral GTPase binding
Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; axon guidance; cell migration; protein deubiquitination; positive regulation of protein binding; regulation of autophagy; endocytosis; cellular response to starvation; negative regulation of protein binding; centrosome duplication; regulation of G-protein coupled receptor protein signaling pathway
Research Articles on USP33
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Product Notes
The Human USP33 usp33 (Catalog #AAA9332412) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332412 ELISA Kit recognizes Human USP33. It is sometimes possible for the material contained within the vial of "ubiquitin specific peptidase 33, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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