Ubiquitin carboxyl-terminal hydrolase 27 (USP27X) Recombinant Protein | USP27X recombinant protein

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 27 (USP27X)

Cat. Num. AAA1087543

• Gene Names: USP27X; USP27; MRX105; USP22L
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin carboxyl-terminal hydrolase 27 (USP27X); Recombinant Human Ubiquitin carboxyl-terminal hydrolase 27 (USP27X); USP27X recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-438, Full length protein
• Sequence: MCKDYVYDKDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLGEKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEMNTQAY
• Sequence Length: 438

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 223005906
• NCBI GeneID: 389856
• NCBI Accession #: NP_001138545.1
• NCBI GenBank Nucleotide #: NM_001145073.2
• UniProt Accession #: A6NNY8
• Molecular Weight: 49,630 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 27
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 27, X-linked
• NCBI Official Symbol: USP27X
• NCBI Official Synonym Symbols: USP27; MRX105; USP22L
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 27
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 27
• UniProt Gene Name: USP27X
• UniProt Synonym Gene Names: USP22L; USP27

NCBI Description

This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016]

Uniprot Description

Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity.