Rat ubiquitin specific peptidase 19 ELISA Kit | USP19 elisa kit
Rat Ubiquitin carboxyl-terminal hydrolase 19, USP19 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
USP19: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. Belongs to the peptidase C19 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Membrane protein, integral; Protease; Ubiquitin-specific protease; EC 3.4.19.12
Cellular Component: endoplasmic reticulum membrane; cytoplasm; integral to membrane; cytosol
Molecular Function: cysteine-type endopeptidase activity; metal ion binding; ubiquitin-specific protease activity
Biological Process: negative regulation of skeletal muscle development; ER-associated protein catabolic process; protein deubiquitination; regulation of protein stability; proteolysis
Research Articles on USP19
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Product Notes
The Rat USP19 usp19 (Catalog #AAA9343095) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343095 ELISA Kit recognizes Rat USP19. It is sometimes possible for the material contained within the vial of "ubiquitin specific peptidase 19, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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