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Uroporphyrinogen Decarboxylase Recombinant Protein | UROD recombinant protein
Recombinant Uroporphyrinogen Decarboxylase (UROD)
Source: Prokaryotic expression
NGLGLQNFPE LKNDTFLRAA WGEETDYTPV WCMRQAGRYL PEFRETRAAQDFFSTCRSPE ACCELTLEPV RRFPLDAAII FSDILVVPQA LAMEVTMVPGKGPSFPEPLR EERDLERLRD PAAVASELGY VFQAITLTRQ QLAGRVPLIGFAGAPWTLMT YMVEGGSFKT MAQAKRWLYQ KPVASHKLLG ILTHALVPYLIGQVAAGAQA LQLFESHAGH LGSELFSKFA LPYIRDVAKR VKAGLQKAGLTRMPMIIFAK DGHFALEELA QAGYEVVGLD WTVAPKKARE PVGKTVTLQGELDPCALYAS EEEIGRLVQQ MLNDFGPQRY IANLGHGLYP DMDPEHVGAFLDAVHKHSRL LRQN
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]
Uniprot Description
UROD: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT); also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda sporadic type or type I. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol- associated liver disease. Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP). HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda. Belongs to the uroporphyrinogen decarboxylase family.
Protein type: EC 4.1.1.37; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Lyase
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: nucleoplasm; cytoplasm; cytosol
Molecular Function: uroporphyrinogen decarboxylase activity
Biological Process: porphyrin metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process
Disease: Porphyria Cutanea Tarda
Research Articles on UROD
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Product Notes
The UROD urod (Catalog #AAA2029336) is a Recombinant Protein produced from Host: E Coli Source: Prokaryotic expression and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Uroporphyrinogen Decarboxylase can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the UROD urod for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.NGLGLQNFP E LKNDTFLRAA WGEETDYTPV WCMRQAGRYL PEFRETRAAQ DFFSTCRSPE ACCELTLEPV RRFPLDAAII FSDILVVPQA LAMEVTMVPG KGPSFPEPLR EERDLERLRD PAAVASELGY VFQAITLTRQ QLAGRVPLIG FAGAPWTLMT YMVEGGSFKT MAQAKRWLYQ KPVASHKLLG ILTHALVPYL IGQVAAGAQA LQLFESHAGH LGSELFSKFA LPYIRDVAKR VKAGLQKAGL TRMPMIIFAK DGHFALEELA QAGYEVVGLD WTVAPKKARE PVGKTVTLQG ELDPCALYAS EEEIGRLVQQ MLNDFGPQRY IANLGHGLYP DMDPEHVGAF LDAVHKHSRL LRQN. It is sometimes possible for the material contained within the vial of "Uroporphyrinogen Decarboxylase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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