Uri1 recombinant protein

Recombinant Mouse Uri1 protein, N- GST Tag

Cat. Num. AAA157639

• Gene Names: Uri1; Rmp; NNX3; C80913
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Uri1; Recombinant Mouse Uri1 protein; N- GST Tag; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; Nnx3; Ppp1r19; Rmp; Uri; Uri1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from 50 mM Tris-HCl, pH8.0, 150 mM NaCl, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Source: Mouse
• Construction: A DNA sequence encoding the Mouse Uri1 (Met1-Ser531) was fused with the N-terminal GST Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder. They are shipped out with blue ice unless customers require otherwise

Product Categories/Family for Uri1 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 254675261
• NCBI GeneID: 19777
• NCBI Accession #: NP_035404.4
• NCBI GenBank Nucleotide #: NM_011274.5
• UniProt Accession #: Q3TLD5; Q3V078; Q8R5C4; Q9Z243
• Molecular Weight: 50,634 Da
• NCBI Official Full Name: unconventional prefoldin RPB5 interactor
• NCBI Official Synonym Full Names: URI1, prefoldin-like chaperone
• NCBI Official Symbol: Uri1
• NCBI Official Synonym Symbols: Rmp; NNX3; C80913
• NCBI Protein Information: unconventional prefoldin RPB5 interactor
• UniProt Protein Name: Unconventional prefoldin RPB5 interactor
• Protein Family: Unconventional prefoldin RPB5 interactor
• UniProt Gene Name: Uri1
• UniProt Synonym Gene Names: Nnx3; Ppp1r19; Rmp; Uri; RPB5-mediating protein
• UniProt Entry Name: RMP_MOUSE

Uniprot Description

RMP: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occurs in a growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminus region) with GTF2F1 and GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT. Ubiquitous. Expressed in ovarian cancers. Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. Belongs to the RNA polymerase II subunit 5-mediating protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Cellular Component: cell projection; mitochondrion; cytoplasm; DNA-directed RNA polymerase II, core complex; nucleus

Molecular Function: phosphatase inhibitor activity; chromatin binding; protein phosphatase inhibitor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; negative regulation of transcription from RNA polymerase II promoter; regulation of cell growth