Unconventional prefoldin RPB5 interactor 1 (URI1) Recombinant Protein | URI1 recombinant protein

Recombinant Human Unconventional prefoldin RPB5 interactor 1 (URI1)

Cat. Num. AAA1028933

• Gene Names: URI1; RMP; URI; NNX3; C19orf2; PPP1R19
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Unconventional prefoldin RPB5 interactor 1 (URI1); Recombinant Human Unconventional prefoldin RPB5 interactor 1 (URI1); URI1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-535, Full length protein
• Sequence: MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKCDFEFKAKHRIAHKPHSKPKTSDIFEADIANDVKSKDLLADKELWARLEELERQEELLGELDSKPDTVIANGEDTTSSEEEKEDRNTNVNAMHQVTDSHTPCHKDVASSEPFSGQVNSQLNCSVNGSSSYHSDDDDDDDDDDDDDNIDDDDGDNDHEALGVGDNSIPTIYFSHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKNSTGSGHSAQELPTIRTPADIYRAFVDVVNGEYVPRKSILKSRSRENSVCSDTSESSAAEFDDRRGVLRSISCEEATCSDTSESILEEEPQENQKKLLPLSVTPEAFSGTVIEKEFVSPSLTPPPAIAHPALPTIPERKEVLLEASEETGKRVSKFKAARLQQKD
• Sequence Length: 535

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for URI1 recombinant protein

This protein binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 358001077
• NCBI GeneID: 8725
• NCBI Accession #: NP_001239570.1
• NCBI GenBank Nucleotide #: NM_001252641.1
• UniProt Accession #: O94763; Q8TC23; Q9UNU3; A8K805; H7BY42
• Molecular Weight: 53,447 Da
• NCBI Official Full Name: unconventional prefoldin RPB5 interactor 1 isoform c
• NCBI Official Synonym Full Names: URI1, prefoldin like chaperone
• NCBI Official Symbol: URI1
• NCBI Official Synonym Symbols: RMP; URI; NNX3; C19orf2; PPP1R19
• NCBI Protein Information: unconventional prefoldin RPB5 interactor 1
• UniProt Protein Name: Unconventional prefoldin RPB5 interactor 1
• Protein Family: Unconventional prefoldin RPB5 interactor
• UniProt Gene Name: URI1
• UniProt Synonym Gene Names: C19orf2; NNX3; PPP1R19; RMP; URI; RPB5-mediating protein

NCBI Description

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

Uniprot Description

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.