Rat unc-13 homolog A (C. elegans) ELISA Kit | UNC13A elisa kit
Rat Protein unc-13 homolog A, UNC13A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
brain specific protein that may have role during neurotransmitter release [RGD, Feb 2006]
Uniprot Description
UNC13A: involved in secretory granule priming in insulin secretion and vesicle maturation during exocytosis. A target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Interacts with RIMS1, BSN, DOC2A, and STX1A or STX1B1. Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester.
Protein type: Membrane protein, peripheral
Cellular Component: presynaptic membrane; neuron projection; protein complex; axon; cytoplasm; terminal button; excitatory synapse; synapse; cell junction; neuromuscular junction
Molecular Function: diacylglycerol binding; protein domain specific binding; SNARE binding; protein homodimerization activity; protein heterodimerization activity; metal ion binding; syntaxin-1 binding; protein N-terminus binding
Biological Process: synaptic transmission, glutamatergic; synaptic vesicle maturation; beta-amyloid metabolic process; neurotransmitter secretion; regulation of short-term neuronal synaptic plasticity; synaptic vesicle priming; positive regulation of neurotransmitter secretion; neuromuscular junction development; synaptic vesicle docking during exocytosis
Research Articles on UNC13A
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Product Notes
The Rat UNC13A unc13a (Catalog #AAA9343390) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343390 ELISA Kit recognizes Rat UNC13A. It is sometimes possible for the material contained within the vial of "unc-13 homolog A (C. elegans), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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