UDP-glucuronosyltransferase 1-6 (UGT1A6) Recombinant Protein | UGT1A6 recombinant protein
Recombinant Human UDP-glucuronosyltransferase 1-6 (UGT1A6)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Description
Ugt1a6a: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.4.1.17; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - ascorbate and aldarate; Membrane protein, integral; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - pentose and glucuronate interconversions; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: protein homodimerization activity; enzyme binding; retinoic acid binding; protein heterodimerization activity; glucuronosyltransferase activity
Biological Process: negative regulation of transferase activity; flavonoid biosynthetic process; xenobiotic metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process; cellular response to hormone stimulus
Research Articles on UGT1A6
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Product Notes
The UGT1A6 ugt1a6 (Catalog #AAA966124) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 27-532. The amino acid sequence is listed below: DKLLVVPQDG SHWLSMKDIV EVLSDRGHEI VVVVPEVNLL LKESKYYTRK IYPVPYDQEE LKNRYQSFGN NHFAERSFLT APQTEYRNNM IVIGLYFINC QSLLQDRDTL NFFKESKFDA LFTDPALPCG VILAEYLGLP SVYLFRGFPC SLEHTFSRSP DPVSYIPRCY TKFSDHMTFS QRVANFLVNL LEPYLFYCLF SKYEELASAV LKRDVDIITL YQKVSVWLLR YDFVLEYPRP VMPNMVFIGG INCKKRKDLS QEFEAYINAS GEHGIVVFSL GSMVSEIPEK KAMAIADALG KIPQTVLWRY TGTRPSNLAN NTILVKWLPQ NDLLGHPMTR AFITHAGSHG VYESICNGVP MVMMPLFGDQ MDNAKRMETK GAGVTLNVLE MTSEDLENAL KAVINDKSYK ENIMRLSSLH KDRPVEPLDL AVFWVEFVMR HKGAPHLRPA AHDLTWYQYH SLDVIGFLLA VVLTVAFITF KCCAYGYRKC LGKKGRVKKA HKSKTH. It is sometimes possible for the material contained within the vial of "UDP-glucuronosyltransferase 1-6 (UGT1A6), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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