Human ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) ELISA Kit | UBE2D2 elisa kit
Human Ubiquitin-conjugating enzyme E2 D2, UBE2D2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Uniprot Description
UBE2D2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family.
Protein type: Ubiquitin ligase; Ligase; EC 6.3.2.19; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: nucleoplasm; protein complex; cytosol; ubiquitin ligase complex
Molecular Function: protein binding; ubiquitin-protein ligase activity; ATP binding; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; protein polyubiquitination; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein modification process; protein ubiquitination; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway
Research Articles on UBE2D2
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Product Notes
The Human UBE2D2 ube2d2 (Catalog #AAA9332974) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332974 ELISA Kit recognizes Human UBE2D2. It is sometimes possible for the material contained within the vial of "ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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