Rat ubiquitin-conjugating enzyme E2B (RAD6 homolog) ELISA Kit | UBE2B elisa kit
Rat Ubiquitin-conjugating enzyme E2 B, UBE2B ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth
Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
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Product Notes
The Rat UBE2B ube2b (Catalog #AAA9335621) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335621 ELISA Kit recognizes Rat UBE2B. It is sometimes possible for the material contained within the vial of "ubiquitin-conjugating enzyme E2B (RAD6 homolog), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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