Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) Recombinant Protein | UBASH3A recombinant protein

Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A)

Cat. Num. AAA960633

• Gene Names: UBASH3A; TULA; CLIP4; STS-2; TULA-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A); Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A); UBASH3A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-661, Full length protein
• Sequence: MAAGETQLYAKVSNKLKSRSSPSLLEPLLAMGFPVHTALKALAATGRKTAEEALAWLHDHCNDPSLDDPIPQEYALFLCPTGPLLEKLQEFWRESKRQCAKNRAHEVFPHVTLCDFFTCEDQKVECLYEALKRAGDRLLGSFPTAVPLALHSSISYLGFFVSGSPADVIREFAMTFATEASLLAGTSVSRFWIFSQVPGHGPNLRLSNLTRASFVSHYILQKYCSVKPCTKQLHLTLAHKFYPHHQRTLEQLARAIPLGHSCQWTAALYSRDMRFVHYQTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFLPENYTDRASESDTWVKHRMYTFSLATDLNSRKDGEASSRCSGEFLPQTARSLSSLQALQATVARKSVLVVRHGERVDQIFGKAWLQQCSTPDGKYYRPDLNFPCSLPRRSRGIKDFENDPPLSSCGIFQSRIAGDALLDSGIRISSVFASPALRCVQTAKLILEELKLEKKIKIRVEPGIFEWTKWEAGKTTPTLMSLEELKEANFNIDTDYRPAFPLSALMPAESYQEYMDRCTASMVQIVNTCPQDTGVILIVSHGSTLDSCTRPLLGLPPRECGDFAQLVRKIPSLGMCFCEENKEEGKWELVNPPVKTLTHGANAAFNWRNWISGN
• Sequence Length: 661

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 49640014
• NCBI GeneID: 53347
• NCBI Accession #: NP_001001895.1
• NCBI GenBank Nucleotide #: NM_001001895.2
• UniProt Accession #: P57075; Q6HA34; Q6HA35; Q6ISI6; Q6ISK3; Q6ISS9; G5E9E4
• Molecular Weight: 59,167 Da
• NCBI Official Full Name: ubiquitin-associated and SH3 domain-containing protein A isoform 2
• NCBI Official Synonym Full Names: ubiquitin associated and SH3 domain containing A
• NCBI Official Symbol: UBASH3A
• NCBI Official Synonym Symbols: TULA; CLIP4; STS-2; TULA-1
• NCBI Protein Information: ubiquitin-associated and SH3 domain-containing protein A
• UniProt Protein Name: Ubiquitin-associated and SH3 domain-containing protein A
• Protein Family: Ubiquitin-associated and SH3 domain-containing protein
• UniProt Gene Name: UBASH3A
• UniProt Synonym Gene Names: STS2; CLIP4; STS-2; TULA-1

NCBI Description

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Description

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.