Tyrosine-protein kinase receptor TYRO3 (Tyro3) Recombinant Protein | Tyro3 recombinant protein

Recombinant Rat Tyrosine-protein kinase receptor TYRO3 (Tyro3), partial

Cat. Num. AAA959497

• Gene Names: Tyro3; Brt
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tyrosine-protein kinase receptor TYRO3 (Tyro3); Recombinant Rat Tyrosine-protein kinase receptor TYRO3 (Tyro3); partial; Tyro3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 31-419
• Sequence: AGLKLMGAPV KMTVSQGQPV KLNCSVEGMD DPDIHWMKDG AVVQNASQVS ISISEQNWIG LLSLKSAERS DAGLYWCQVK DGEETKISQS VWLTVEGVPF FTVEPKDLAV PPNVPFQLSC EAVGPPEPVT IFWWRGPTKV GGPASSPSVL NVTGVTQRTE FSCEAHNIKG LATSRPAIIR LQAPPAAPFN ITVTTISSSN ASVAWVPGAD GLALLHSCTV QVAHAPGEWE ALAVVVPVPP FTCLLRNLAP ATNYSLRVRC ANALGPSPYG DWVPFQTKGL APARAPQNFH AIRTDSGLIL EWEEVIPEDP GEGPLGPYKL SWVQENGTQD ELMVEGTTAN LTDWDPQKDL VLRVCASNAI GDGPWSQPLV VSSHDHAGRQ GPPHSRTSW
• Sequence Length: 389

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 8394496
• NCBI GeneID: 25232
• NCBI Accession #: NP_058788.1
• NCBI GenBank Nucleotide #: NM_017092.1
• UniProt Accession #: P55146
• Molecular Weight: 95,919 Da
• NCBI Official Full Name: tyrosine-protein kinase receptor TYRO3
• NCBI Official Synonym Full Names: TYRO3 protein tyrosine kinase
• NCBI Official Symbol: Tyro3
• NCBI Official Synonym Symbols: Brt
• NCBI Protein Information: tyrosine-protein kinase receptor TYRO3
• UniProt Protein Name: Tyrosine-protein kinase receptor TYRO3
• Protein Family: Tyrosine-protein kinase receptor
• UniProt Gene Name: Tyro3
• UniProt Synonym Gene Names: Sky

NCBI Description

receptor tyrosine kinase; may have a role in development or function of specific neuronal populations [RGD, Feb 2006]

Uniprot Description

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 ().