Human Thromboxane synthase ELISA Kit | TXS elisa kit

Human Thromboxane synthase ELISA Kit

Cat. Num. AAA732665

• Gene Names: TBXAS1; TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14
• Reactivity: Human
• Synonyms: Thromboxane synthase; Human Thromboxane synthase ELISA Kit; TXS elisa kit

• Reactivity: Human

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for TXS elisa kit

Intended Uses: This B.GTTRELISA kit is intended Laboratory for research use only.The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofTTR in the sample, thisTTR ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusTTR concentration. The concentration ofTTR in the samples is then determined by comparing the O.D. of the samples to the standard curve.

Principle of the Assay: This B.GTTRELISA kit is intended Laboratory for research use only.The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofTTR in the sample, thisTTR ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusTTR concentration. The concentration ofTTR in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 1325919
• NCBI GeneID: 6916
• Molecular Weight: 52,287 Da
• NCBI Official Full Name: thromboxane synthase
• NCBI Official Synonym Full Names: thromboxane A synthase 1 (platelet)
• NCBI Official Symbol: TBXAS1
• NCBI Official Synonym Symbols: TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14
• NCBI Protein Information: thromboxane-A synthase; TXA synthase; cytochrome P450 5A1; platelet, cytochrome P450, subfamily V; cytochrome P450, family 5, subfamily A, polypeptide 1
• UniProt Protein Name: Thromboxane-A synthase
• UniProt Gene Name: TBXAS1
• UniProt Synonym Gene Names: CYP5; CYP5A1; TXA synthase; TXS
• UniProt Entry Name: THAS_HUMAN

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Description

TBXAS1: Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD). GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all. Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency). It is characterized by hemorrhagic diathesis. Belongs to the cytochrome P450 family.

Protein type: Lipid Metabolism - arachidonic acid; Membrane protein, integral; EC 5.3.99.5; Oxidoreductase; Isomerase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q34-q35

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; thromboxane-A synthase activity; iron ion binding; heme binding; monooxygenase activity

Biological Process: xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; positive regulation of vasoconstriction; arachidonic acid metabolic process; cellular chloride ion homeostasis

Disease: Ghosal Hematodiaphyseal Dysplasia; Bleeding Disorder, Platelet-type, 14