Thioredoxin-interacting protein Recombinant Protein | Txnip recombinant protein

Recombinant Mus musculus Thioredoxin-interacting protein

Cat. Num. AAA969733

• Gene Names: Txnip; THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Thioredoxin-interacting protein; Recombinant Mus musculus Thioredoxin-interacting protein; Txnip recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-397, Full length protein
• Sequence: MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEEQPTAGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVFTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILKVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDIIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNNNVQ
• Sequence Length: 397

• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 60687518
• NCBI GeneID: 56338
• NCBI Accession #: NP_001009935.1
• NCBI GenBank Nucleotide #: NM_001009935.2
• UniProt Accession #: Q8BG60; Q8BGQ0; Q8K2B2; Q9DC00; Q9EP90; Q9R115
• Molecular Weight: 44,292 Da
• NCBI Official Full Name: thioredoxin-interacting protein isoform 1
• NCBI Official Synonym Full Names: thioredoxin interacting protein
• NCBI Official Symbol: Txnip
• NCBI Official Synonym Symbols: THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik
• NCBI Protein Information: thioredoxin-interacting protein
• UniProt Protein Name: Thioredoxin-interacting protein
• Protein Family: Thioredoxin-interacting protein
• UniProt Gene Name: Txnip
• UniProt Synonym Gene Names: Vdup1

Uniprot Description

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.