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Twinkle protein, mitochondrial (PEO1) Recombinant Protein | PEO1 recombinant protein
Recombinant Human Twinkle protein, mitochondrial (PEO1)
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Aug 2009]
Uniprot Description
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.
Research Articles on PEO1
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Product Notes
The PEO1 twnk (Catalog #AAA1433299) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 32-684aa; Full Length of Mature Protein. The amino acid sequence is listed below: APGPPRRRYR KETLQALDMP VLPVTATEIR QYLRGHGIPF QDGHSCLRAL SPFAESSQLK GQTGVTTSFS LFIDKTTGHF LCMTSLAEGS WEDFQASVEG RGDGAREGFL LSKAPEFEDS EEVRRIWNRA IPLWELPDQE EVQLADTMFG LTKVTDDTLK RFSVRYLRPA RSLVFPWFSP GGSGLRGLKL LEAKCQGDGV SYEETTIPRP SAYHNLFGLP LISRRDAEVV LTSRELDSLA LNQSTGLPTL TLPRGTTCLP PALLPYLEQF RRIVFWLGDD LRSWEAAKLF ARKLNPKRCF LVRPGDQQPR PLEALNGGFN LSRILRTALP AWHKSIVSFR QLREEVLGEL SNVEQAAGLR WSRFPDLNRI LKGHRKGELT VFTGPTGSGK TTFISEYALD LCSQGVNTLW GSFEISNVRL ARVMLTQFAE GRLEDQLDKY DHWADRFEDL PLYFMTFHGQ QSIRTVIDTM QHAVYVYDIC HVIIDNLQFM MGHEQLSTDR IAAQDYIIGV FRKFATDNNC HVTLVIHPRK EDDDKELQTA SIFGSAKASQ EADNVLILQD RKLVTGPGKR YLQVSKNRFD GDVGVFPLEF NKNSLTFSIP PKNKARLKKI KDDTGPVAKK PSSGKKGATT QNSEICSGQA PTPDQPDTSK RSK . It is sometimes possible for the material contained within the vial of "Twinkle protein, mitochondrial (PEO1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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