Uniprot Description
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Product Notes
The TTHERM_00355780 ttherm_00355780 (Catalog #
AAA1483914) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-399, Full length protein. The amino acid sequence is listed below: MEFNFIINKL VQLDQQGLGV YIPRASRSKV SSQQEQQLGQ VLNTMGERSA IAQGLKQVIT NYDKVQGTDQ RVYIVAEGRT CQGFLKVGQK NLFYRDMMGN IKEIKPLCVL DFYVHESCQR QGYGKLLFEY MIQCEQTSPE KLAYDRPSPK LIAFLKKHYN LVKYIAQNNN FVVFDQYFRS DASSQNKQNQ NTRSYSQPYS DYSSQIPTNY PQQQQQQSNS KSYPYKQENN IDLMQHSSSR NNKEFLNAGR AILSKEEIYK KDNLSQQNIE NTLNNINNSQ YSTKSQQQQQ YQKDYQLDKY ENNWGADKNI KKPPFPGQDR QLDKIQQKIQ QTERELDVVN QQIIKQRQNL SQDPLTQNHR AQNVYNTNQF GTSPWAQTGF NYYSTSSSNY GNHYTYYKK.
It is sometimes possible for the material contained within the vial of
"Alpha-tubulin N-acetyltransferase (TTHERM_00355780), Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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