Translin Blocking Peptide | TSN blocking peptide

Translin Peptide

Cat. Num. AAA151789

• Gene Names: TSN; C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1
• Applications: Blocking (BL)
• Synonyms: Translin; Translin Peptide; C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1; Component 3 of promoter of RISC; translin; TSN blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 228

• Applicable Applications for TSN blocking peptide: Blocking (BL)
• Application Notes: Translin peptide is used for blocking the activity of Translin antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 20 amino acids near the carboxy terminus of human Translin.
• Preparation and Storage: Store Translin peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 4759270
• NCBI GeneID: 7247
• NCBI Accession #: NP_004613
• NCBI GenBank Nucleotide #: NM_004622.2
• UniProt Accession #: Q15631; Q5U0K7; B7Z3X8
• Molecular Weight: 17,279 Da
• NCBI Official Full Name: translin isoform 1
• NCBI Official Synonym Full Names: translin
• NCBI Official Symbol: TSN
• NCBI Official Synonym Symbols: C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1
• NCBI Protein Information: translin; component 3 of promoter of RISC; testis brain-RNA binding protein; recombination hotspot-binding protein; recombination hotspot associated factor
• UniProt Protein Name: Translin
• Protein Family: Translin
• UniProt Gene Name: TSN
• UniProt Synonym Gene Names: C3PO
• UniProt Entry Name: TSN_HUMAN

NCBI Description

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Uniprot Description

TSN: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Belongs to the translin family.

Protein type: EC 3.1.-.-; DNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2q21.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: endoribonuclease activity; mRNA binding; protein binding; DNA binding; sequence-specific DNA binding; protein complex binding; single-stranded DNA binding

Biological Process: gene expression; DNA recombination