TRS (Threonyl-tRNA Synthetase) Recombinant Protein | TRS recombinant protein

TRS (Threonyl-tRNA Synthetase)

Cat. Num. AAA490324

• Gene Names: ThrRS; 42/3; Aats-thr; CG5353; DmelCG5353; l(2)k04203; P539; threonyl-tRNA synthetase; TRS
• Purity: >90%; Multi-Step Chromatography
• Synonyms: TRS (Threonyl-tRNA Synthetase); Threonyl tRNA Synthetase Protein; TRS recombinant protein

• Host: E Coli
• Purity/Purification: >90%; Multi-Step Chromatography
• Form/Format: 1X PBS (pH7.2) 200mM NaCl 20% Glycerol
• Concentration: 0.50 mg/ml (varies by lot)
• Sequence Length: Full Length

• Source: Human
• Conjugation/Tag: C-term 6XHis tag
• Preparation and Storage: Store at -70 degree C.

SDS-Page

Related Product Information for TRS recombinant protein

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase.

References

1. Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment. Jiqiang Ling et al., PNAS Early Edition, 3281-3286, 2012. 2. Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum. Katherine E. Jackson et al., International Journal for Parasitology, Vol.42, 177-186, 2012. 3. Post-transfer editing mechanism of a D-aminoacyltRNA deacylase-like domain in threonyl-tRNA synthetase from archaea. Hussain T et al., EMBO J., Vol.25, 4152-4162, 2006. 4. Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis. Yamasaki Y. et al., Arthritis Rheum., Vol.54, 2004-2009, 2006. 5. A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan B. et al., J. Biol. Chem., Vol.280, 571-577, 2004. 6. Threonyl-tRNA synthetase of archaea: importance of the discriminator base in the aminoacylation of threonine tRNA. Ishikura H. et al., Nucleic Acids Symp. Ser., Vol.44, 83-84, 2000. 7. Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase. Torres-Larios A. et al., J. Mol. Biol., Vol.331, 201-211, 2003.

NCBI and Uniprot Product Information

• NCBI GI #: 665407764
• NCBI GeneID: 45784
• NCBI Accession #: NP_001285868.1
• NCBI GenBank Nucleotide #: NM_001298939.1
• Molecular Weight: 83kDa
• NCBI Official Full Name: Threonyl-tRNA synthetase, isoform D
• NCBI Official Synonym Full Names: Threonyl-tRNA synthetase
• NCBI Official Symbol: ThrRS
• NCBI Official Synonym Symbols: 42/3; Aats-thr; CG5353; DmelCG5353; l(2)k04203; P539; threonyl-tRNA synthetase; TRS
• NCBI Protein Information: Threonyl-tRNA synthetase
• Protein Family: Trypanothione synthetase