Rabbit transient receptor potential cation channel, subfamily V, member 4 ELISA Kit | TRPV4 elisa kit
Rabbit Transient receptor potential Cation channel subfamily V member 4, TRPV4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
a cation-selective channel; activated in response to systemic osmotic pressure [RGD, Feb 2006]
Uniprot Description
TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass
Cellular Component: cortical actin cytoskeleton; cell surface; focal adhesion; cell; integral to membrane; cilium; growth cone; adherens junction; cytoplasmic microtubule; lamellipodium; plasma membrane; cytoplasmic vesicle; filopodium
Molecular Function: microtubule binding; calcium channel activity; beta-tubulin binding; actin binding; protein kinase binding; calmodulin binding; actin filament binding; protein binding; protein kinase C binding; osmosensor activity; SH2 domain binding; cation channel activity; alpha-tubulin binding; ATP binding
Biological Process: intercellular junction assembly; hypotonic response; actin filament organization; response to osmotic stress; regulation of response to osmotic stress; osmosensory signaling pathway; cellular calcium ion homeostasis; vasopressin secretion; elevation of cytosolic calcium ion concentration; positive regulation of microtubule depolymerization; hyperosmotic salinity response; calcium ion transport; actin cytoskeleton reorganization; cortical microtubule organization and biogenesis; microtubule polymerization
Research Articles on TRPV4
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Product Notes
The Rabbit TRPV4 trpv4 (Catalog #AAA9310828) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9310828 ELISA Kit recognizes Rabbit TRPV4. It is sometimes possible for the material contained within the vial of "transient receptor potential cation channel, subfamily V, member 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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