Human transient receptor potential cation channel, subfamily M, member 8 ELISA Kit | TRPM8 elisa kit
Human Transient receptor potential Cation channel subfamily M member 8, TRPM8 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: endoplasmic reticulum membrane; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane
Molecular Function: protein binding; protein homodimerization activity; calcium channel activity
Biological Process: cellular calcium ion homeostasis; detection of temperature stimulus; thermoception; response to cold; transmembrane transport; protein homotetramerization
Research Articles on TRPM8
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Product Notes
The Human TRPM8 trpm8 (Catalog #AAA9328644) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328644 ELISA Kit recognizes Human TRPM8. It is sometimes possible for the material contained within the vial of "transient receptor potential cation channel, subfamily M, member 8, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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