Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Recombinant Protein | TRPM4 recombinant protein

Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4)

Cat. Num. AAA2124623

• Gene Names: Trpm4; Mls2s; LTrpC-4
• Applications: SDS-Page, Western Blot
• Purity: >97%
• Synonyms: Transient Receptor Potential Cation Channel Subfamily M; Member 4 (TRPM4); Recombinant Transient Receptor Potential Cation Channel Subfamily M; Member 4; TRPM4B; Melastatin-4; Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4; TRPM4 recombinant protein

• Host: E Coli
• Purity/Purification: >97%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence: Met1~Leu400

• Applicable Applications for TRPM4 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Rat
• Tag: N-terminal His Tag
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Isoelectric Point: 5.3
• Subcellular Location: Membrane
• Usage: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for TRPM4 recombinant protein

Signal transduction; Recombinant proteins/RP

NCBI and Uniprot Product Information

• NCBI GI #: 209977101
• NCBI GeneID: 171143
• NCBI Accession #: NP_001129701.1
• NCBI GenBank Nucleotide #: NM_001136229.1
• UniProt Accession #: Q9ESQ5
• Molecular Weight: 115,277 Da
• NCBI Official Full Name: transient receptor potential cation channel subfamily M member 4
• NCBI Official Synonym Full Names: transient receptor potential cation channel, subfamily M, member 4
• NCBI Official Symbol: Trpm4
• NCBI Official Synonym Symbols: Mls2s; LTrpC-4
• NCBI Protein Information: transient receptor potential cation channel subfamily M member 4
• UniProt Protein Name: Transient receptor potential cation channel subfamily M member 4
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: Trpm4
• UniProt Synonym Gene Names: Ltrpc4; LTrpC-4; LTrpC4

NCBI Description

member of a family of calcium permeable channels [RGD, Feb 2006]

Uniprot Description

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells ().