Human transient receptor potential cation channel, subfamily M, member 2 ELISA Kit | TRPM2 elisa kit
Human Transient receptor potential Cation channel subfamily M member 2, TRPM2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Uniprot Description
TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter; Hydrolase; Channel, calcium; Membrane protein, integral; EC 3.6.1.13
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: ADP-ribose diphosphatase activity; calcium channel activity; sodium channel activity; manganese ion transmembrane transporter activity
Biological Process: response to hydroperoxide; metabolic process; calcium ion transport; transmembrane transport
Research Articles on TRPM2
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Product Notes
The Human TRPM2 trpm2 (Catalog #AAA9338289) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338289 ELISA Kit recognizes Human TRPM2. It is sometimes possible for the material contained within the vial of "transient receptor potential cation channel, subfamily M, member 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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