Human transient receptor potential cation channel, subfamily C, member 6 ELISA Kit | TRPC6 elisa kit
Human Short transient receptor potential channel 6, TRPC6 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
Uniprot Description
TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation
Chromosomal Location of Human Ortholog: 11q22.1
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding; store-operated calcium channel activity
Biological Process: positive regulation of ion transmembrane transporter activity; platelet activation; axon guidance; elevation of cytosolic calcium ion concentration; blood coagulation; positive regulation of calcium ion transport; transmembrane transport; cation transport; aging
Disease: Focal Segmental Glomerulosclerosis 2
Research Articles on TRPC6
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Product Notes
The Human TRPC6 trpc6 (Catalog #AAA9330948) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330948 ELISA Kit recognizes Human TRPC6. It is sometimes possible for the material contained within the vial of "transient receptor potential cation channel, subfamily C, member 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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