Human thyroid hormone receptor interactor 11 ELISA Kit | TRIP11 elisa kit
Human Thyroid receptor-interacting protein 11, TRIP11 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
Uniprot Description
TRIP11: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia. Defects in TRIP11 are the cause of achondrogenesis type 1A (ACG1A). A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 14q31-q32
Cellular Component: Golgi membrane; Golgi apparatus; inner acrosomal membrane; cis-Golgi network; cytoskeleton; nucleus
Molecular Function: protein binding; transcription coactivator activity
Biological Process: transcription from RNA polymerase II promoter; organelle organization and biogenesis; protein targeting to Golgi
Disease: Achondrogenesis, Type Ia
Research Articles on TRIP11
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Product Notes
The Human TRIP11 trip11 (Catalog #AAA9334500) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334500 ELISA Kit recognizes Human TRIP11. It is sometimes possible for the material contained within the vial of "thyroid hormone receptor interactor 11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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