Human tripartite motif-containing 25 ELISA Kit | TRIM25 elisa kit
Human E3 ubiquitin/ISG15 ligase TRIM25, TRIM25 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
Uniprot Description
TRIM25: a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.
Protein type: Ubiquitin ligase; EC 6.3.2.n3; Transcription factor; Ubiquitin conjugating system; Ligase; EC 6.3.2.19; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: nucleoplasm; cytoplasm; cytosol
Molecular Function: protein binding; acid-amino acid ligase activity; zinc ion binding; transcription factor activity
Biological Process: response to vitamin D; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; negative regulation of virion penetration into host cell; response to estrogen stimulus; cytokine and chemokine mediated signaling pathway; innate immune response; protein ubiquitination; positive regulation of transcription factor activity; regulation of virion penetration into host cell; defense response to virus; negative regulation of interferon type I production; activation of NF-kappaB transcription factor
Research Articles on TRIM25
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Product Notes
The Human TRIM25 trim25 (Catalog #AAA9318621) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318621 ELISA Kit recognizes Human TRIM25. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 25, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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