Human tripartite motif-containing 13 ELISA Kit | TRIM13 elisa kit

Human E3 ubiquitin-protein ligase TRIM13, TRIM13 ELISA Kit

Cat. Num. AAA9342365

• Gene Names: TRIM13; CAR; LEU5; RFP2; DLEU5; RNF77
• Reactivity: Human
• Synonyms: tripartite motif-containing 13; Human E3 ubiquitin-protein ligase TRIM13; TRIM13 ELISA Kit; Human E3 ubiquitin-protein ligase TRIM13 (TRIM13) ELISA kit; CAR; DLEU5; LEU5; RFP2; RNF77; CLL-associated RING finger; ret finger protein 2; tripartite motif protein 13; TRIM13 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 55953112
• NCBI GeneID: 10206
• NCBI Accession #: NP_001007279.1
• NCBI GenBank Nucleotide #: NM_001007278.2
• UniProt Accession #: O60858; Q5UBW0; Q5W0U8; Q5W0U9; Q9BQ47; Q9C021; B2RB49
• Molecular Weight: 46,988 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase TRIM13 isoform 2
• NCBI Official Synonym Full Names: tripartite motif containing 13
• NCBI Official Symbol: TRIM13
• NCBI Official Synonym Symbols: CAR; LEU5; RFP2; DLEU5; RNF77
• NCBI Protein Information: E3 ubiquitin-protein ligase TRIM13; ret finger protein 2; RING finger protein 77; CLL-associated RING finger; tripartite motif protein 13; leukemia-associated protein 5; putative tumor suppressor RFP2; tripartite motif-containing 13; tripartite motif-containing protein 13; B-cell chronic lymphocytic leukemia tumor suppressor Leu5
• UniProt Protein Name: E3 ubiquitin-protein ligase TRIM13
• Protein Family: Tripartite motif containing
• UniProt Gene Name: TRIM13
• UniProt Synonym Gene Names: LEU5; RFP2; RNF77
• UniProt Entry Name: TRI13_HUMAN

NCBI Description

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TRIM13: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Ligase; Membrane protein, integral; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: endoplasmic reticulum membrane; cytoplasm; integral to membrane

Molecular Function: signal transducer activity; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; negative regulation of viral transcription; protein autoubiquitination; ER-associated protein catabolic process; anatomical structure morphogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; response to gamma radiation; signal transduction; positive regulation of macroautophagy; activation of NF-kappaB transcription factor