Protirelin Native Protein | TRH native protein
Human Thyrotropin Releasing Hormone TRH Human
Sterile Filtered White lyophilized (freeze-dried) powder.
Introduction: Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF), thyroliberin or protirelin, is a tripeptide hormonethat stimulates the release of thyroid-stimulating hormoneand prolactinby the anterior pituitary. TRH is produced by the hypothalamus, near the paraventricular nucleus. It travels across the median eminenceto the pituitary via the hypophyseal portal system. It is released from cells called thyrotropes. In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal systemand pancreatic islets.Protirelin stimulates the secretion of pituitary thyroid stimulating hormone from the anterior pituitary and has been shown that protirelin increases secretion of prolactin. Protirelin is identified as 5-oxo-L-prolyl-L-histidyl-L-proline amide. It is a synthetic tripeptide that is believed to be structurally identical to the naturally-occurring thyrotropin-releasing hormone produced by the hypothalamus.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
Uniprot Description
TRH: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. Belongs to the TRH family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 3q13.3-q21
Cellular Component: plasma membrane; extracellular region; nucleus; secretory granule
Molecular Function: neuropeptide hormone activity; thyrotropin-releasing hormone activity
Biological Process: response to ethanol; negative regulation of glutamate secretion; hormone-mediated signaling; cell-cell signaling; eating behavior; response to glucose stimulus; response to hypoxia; positive regulation of insulin secretion; response to cold; histamine metabolic process; signal transduction; adult walking behavior; positive regulation of gamma-aminobutyric acid secretion; response to corticosterone stimulus
Disease: Thyrotropin-releasing Hormone Deficiency
Research Articles on TRH
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Product Notes
The TRH trh (Catalog #AAA142658) is a Native Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Pyr-His-Pr o-NH2. It is sometimes possible for the material contained within the vial of "Protirelin, Native Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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