Triggering Receptor Expressed On Myeloid Cells 2 Recombinant Protein | TREM2 recombinant protein

Recombinant Triggering Receptor Expressed On Myeloid Cells 2 (TREM2)

Cat. Num. AAA2123841

• Gene Names: TREM2; PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c
• Applications: SDS-Page, Western Blot
• Purity: >95%
• Synonyms: Triggering Receptor Expressed On Myeloid Cells 2; Recombinant Triggering Receptor Expressed On Myeloid Cells 2 (TREM2); Trem2a; Trem2b; Trem2c; Triggering receptor expressed on monocytes 2; TREM2 recombinant protein

• Host: E Coli
• Purity/Purification: >95%
• Form/Format: Freeze-dried powder; 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Sequence Positions: His19~Ser174
• Sequence Length: 230

• Applicable Applications for TREM2 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His Tag
• Subcellular Location: Membrane, Secreted
• Isoelectric Point: 6.3
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

(Figure. SDS-PAGE)

Product Categories/Family for TREM2 recombinant protein

CD & Adhesion molecule

NCBI and Uniprot Product Information

• NCBI GI #: 9507203
• NCBI GeneID: 54209
• NCBI Accession #: NP_061838
• NCBI GenBank Nucleotide #: NP_061838.1
• UniProt Accession #: Q9NZC2
• Molecular Weight: Predicted Molecular Mass: 21.1kDa; Accurate Molecular Mass: 21kDa
• NCBI Official Full Name: triggering receptor expressed on myeloid cells 2 isoform 1
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells 2
• NCBI Official Symbol: TREM2
• NCBI Official Synonym Symbols: PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c
• NCBI Protein Information: triggering receptor expressed on myeloid cells 2
• UniProt Protein Name: Triggering receptor expressed on myeloid cells 2
• Protein Family: Triggering receptor expressed on myeloid cells
• UniProt Gene Name: TREM2
• UniProt Synonym Gene Names: TREM-2

NCBI Description

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Uniprot Description

Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines.