Goat Tartrate Resistant Acid Phosphatase 5B ELISA Kit | TRACP-5B elisa kit
Goat Tartrate Resistant Acid Phosphatase 5B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Uniprot Description
ACP5: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI). A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease. Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
Protein type: Cofactor and Vitamin Metabolism - riboflavin; Phosphatase; Motility/polarity/chemotaxis; EC 3.1.3.2
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: lysosome; integral to membrane; cytosol
Molecular Function: acid phosphatase activity; ferric iron binding; ferrous iron binding
Biological Process: negative regulation of interleukin-12 production; vitamin metabolic process; negative regulation of nitric oxide biosynthetic process; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; negative regulation of superoxide release; negative regulation of interleukin-1 beta production; riboflavin metabolic process; defense response to Gram-positive bacterium; dephosphorylation; response to cytokine stimulus; negative regulation of inflammatory response; water-soluble vitamin metabolic process; bone resorption
Disease: Spondyloenchondrodysplasia With Immune Dysregulation
Research Articles on TRACP-5B
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Product Notes
The Goat TRACP-5B acp5 (Catalog #AAA038121) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA038121 ELISA Kit recognizes Goat TRACP-5B. It is sometimes possible for the material contained within the vial of "Tartrate Resistant Acid Phosphatase 5B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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