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Tryptase beta-2 Recombinant Protein | Tpsb2 recombinant protein
Recombinant Mouse Tryptase beta-2
Gene Names
Tpsb2; Mcp6; Mcp-6; Mcpt6; MMCP-6; AV011504
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Tryptase beta-2; Recombinant Mouse Tryptase beta-2; Mast cell protease 6; mMCP-6; Tpsb2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
32-276. Full Length of Mature Protein
Sequence
IVGGHEASESKWPWQVSLRFKLNYWIHFCGGSLIHPQWVLTAAHCVGPHIKSPQLFRVQLREQYLYYGDQLLSLNRIVVHPHYYTAEGGADVALLELEVPVNVSTHIHPISLPPASETFPPGTSCWVTGWGDIDNDEPLPPPYPLKQVKVPIVENSLCDRKYHTGLYTGDDFPIVHDGMLCAGNTRRDSCQGDSGGPLVCKVKGTWLQAGVVSWGEGCAQPNKPGIYTRVTYYLDWIHRYVPEHS
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
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Related Product Information for Tpsb2 recombinant protein
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K. pneumoniae infection.
References
Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells and mast cells of the connective tissue subclass.Reynolds D.S., Gurley D.S., Austen K.F., Serafin W.E.J. Biol. Chem. 266:3847-3853(1991)
Expression of a mast cell tryptase in the human monocytic cell lines U-937 and Mono Mac 6.Huang R., Abrink M., Gobl A.E., Nilsson G., Aveskogh M., Larsson L.G., Nilsson K., Hellman L.Scand. J. Immunol. 38:359-367(1993)
Genes for mast-cell serine protease and their molecular evolution.Huang R., Hellman L.T.Immunogenetics 40:397-414(1994)
Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases.Reynolds D.S., Stevens R.L., Lane W.S., Carr M.H., Austen K.F., Serafin W.E.Proc. Natl. Acad. Sci. U.S.A. 87:3230-3234(1990)
The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.Thakurdas S.M., Melicoff E., Sansores-Garcia L., Moreira D.C., Petrova Y., Stevens R.L., Adachi R.J. Biol. Chem. 282:20809-20815(2007)
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.J. Immunol. 179:5864-5876(2007)
The expression pattern of three mast cell specific proteases during mouse development.Abraham D., Oster H., Huber M., Leitges M.Mol. Immunol. 44:732-740(2007)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
54.4 kDa
NCBI Official Full Name
Tryptase beta-2
NCBI Official Synonym Full Names
tryptase beta 2
NCBI Official Symbol
Tpsb2
NCBI Official Synonym Symbols
Mcp6; Mcp-6; Mcpt6; MMCP-6; AV011504
NCBI Protein Information
tryptase beta-2
UniProt Protein Name
Tryptase beta-2
Protein Family
UniProt Gene Name
Tpsb2
UniProt Synonym Gene Names
Mcpt6; Tryptase-2; mMCP-6
UniProt Entry Name
TRYB2_MOUSE
Uniprot Description
TPSB2: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection. Belongs to the peptidase S1 family. Tryptase subfamily.
Protein type: Protease; EC 3.4.21.59; Secreted; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular region; extracellular space
Molecular Function: heparin binding; hydrolase activity; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: inflammatory response; proteolysis
Research Articles on Tpsb2
Similar Products
Product Notes
The Tpsb2 tpsb2 (Catalog #AAA963755) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 32-276. Full Length of Mature Protein. The amino acid sequence is listed below: IVGGHEASES KWPWQVSLRF KLNYWIHFCG GSLIHPQWVL TAAHCVGPHI KSPQLFRVQL REQYLYYGDQ LLSLNRIVVH PHYYTAEGGA DVALLELEVP VNVSTHIHPI SLPPASETFP PGTSCWVTGW GDIDNDEPLP PPYPLKQVKV PIVENSLCDR KYHTGLYTGD DFPIVHDGML CAGNTRRDSC QGDSGGPLVC KVKGTWLQAG VVSWGEGCAQ PNKPGIYTRV TYYLDWIHRY VPEHS . It is sometimes possible for the material contained within the vial of "Tryptase beta-2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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