TPO recombinant protein

Recombinant Human TPO Protein

Cat. Num. AAA355849

• Gene Names: TPO; MSA; TPX; TDH2A
• Purity: >90% by SDS-PAGE
• Synonyms: TPO; Recombinant Human TPO Protein; Thyroid peroxidase; thyroperoxidase; iodide peroxidase; TPO recombinant protein

• Host: E Coli
• Purity/Purification: >90% by SDS-PAGE
• Form/Format: Liquid
• Sequence Length: 933

• Storage Buffer: Contains 20mM Tris-HCl (pH8.0).
• Preparation and Storage: Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.; Avoid repeated freeze and thaw cycles.

Related Product Information for TPO recombinant protein

Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. In humans, thyroperoxidase is encoded by the TPO gene. Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). TPO mutations with residual activity are associated with mild TPO deficiency, which is clinically characterized by marked goiter, mild TSH elevation, high serum T3 to T4 molar ratio, and high serum thyroglobulin levels.

References

1. Narumi S, Fox LA, Fukudome K, Sakaguchi Z, Sugisawa C, Abe K, Kameyama K, Hasegawa T. Narumi S, Fox LA, Fukudome K, Sakaguchi Z, Sugisawa C, Abe K, Kameyama K, Hasegawa T. Endocr J. 2017 Sep 1.

Gene Information

NCBI and Uniprot Product Information

• NCBI GI #: 28558982
• NCBI GeneID: 7173
• NCBI Accession #: NP_000538.3
• NCBI GenBank Nucleotide #: NM_000547.5
• UniProt Accession #: P07202; P09934; P09935; Q8IUL0; Q8NF94; Q8NF95; Q8NF96; Q8NF97; Q8TCI9
• Molecular Weight: 92,063 Da
• NCBI Official Full Name: thyroid peroxidase isoform a
• NCBI Official Synonym Full Names: thyroid peroxidase
• NCBI Official Symbol: TPO
• NCBI Official Synonym Symbols: MSA; TPX; TDH2A
• NCBI Protein Information: thyroid peroxidase
• UniProt Protein Name: Thyroid peroxidase
• Protein Family: Thyroid peroxidase
• UniProt Gene Name: TPO
• UniProt Synonym Gene Names: TPO

NCBI Description

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Uniprot Description

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.