Human two pore segment channel 2 ELISA Kit | TPCN2 elisa kit
Human Two pore calcium channel protein 2, TPCN2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]
Uniprot Description
TPCN2: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
Protein type: Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: lysosomal membrane; plasma membrane; integral to membrane; endosome membrane
Molecular Function: voltage-gated calcium channel activity; identical protein binding; protein binding; protein kinase binding
Biological Process: cellular calcium ion homeostasis; smooth muscle contraction; calcium ion transport; release of sequestered calcium ion into cytosol; transmembrane transport
Disease: Skin/hair/eye Pigmentation, Variation In, 10
Research Articles on TPCN2
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Product Notes
The Human TPCN2 tpcn2 (Catalog #AAA9329798) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329798 ELISA Kit recognizes Human TPCN2. It is sometimes possible for the material contained within the vial of "two pore segment channel 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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