Cellular tumor antigen p53 (TP53) Recombinant Protein | TP53 recombinant protein
Recombinant Cricetulus griseus Cellular tumor antigen p53 (TP53)
NCBI and Uniprot Product Information
Uniprot Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
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Product Notes
The TP53 tp53 (Catalog #AAA1187009) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-393, full length protein. The amino acid sequence is listed below: MEEPQSDLSI ELPLSQETFS DLWKLLPPNN VLSTLPSSDS IEELFLSENV TGWLEDSGGA LQGVAAAAAS TAEDPVTETP APVASAPATP WPLSSSVPSY KTYQGDYGFR LGFLHSGTAK SVTCTYSPSL NKLFCQLAKT CPVQLWVNST PPPGTRVRAM AIYKKLQYMT EVVRRCPHHE RSSEGDSLAP PQHLIRVEGN LHAEYLDDKQ TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS SCMGGMNRRP ILTIITLEDP SGNLLGRNSF EVRICACPGR DRRTEEKNFQ KKGEPCPELP PKSAKRALPT NTSSSPPPKK KTLDGEYFTL KIRGHERFKM FQELNEALEL KDAQASKGSE DNGAHSSYLK SKKGQSASRL KKLMIKREGP DSD. It is sometimes possible for the material contained within the vial of "Cellular tumor antigen p53 (TP53), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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